Minarovits, Janos and Banati, Ferenc and Niller, Hans Helmut (2011) Viral hit-and-run tumorigenesis. FUTURE VIROLOGY, 6 (1). pp. 13-15. ISSN 1746-0794,
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Evaluation of: Stevenson PG, May JS, Connor V, Efstathiou S: Vaccination against a hit-and-run viral cancer. J. Gen. Virol. 91, 2176-2185 (2010). Viral hit-and-run oncogenesis scenarios suggest that transient acquisition of viral genomes can induce a permanent change in the gene expression pattern of the host cell, resulting in malignant conversion. Stevenson et al. developed an in vivo model system based on the introduction of a Cre-recombinase positive murid herpesvirus into genetically engineered mice. They demonstrated that the Ore recombinase could switch on a silent oncogene and inactivate a tumor suppressor gene resulting in sarcomagenesis. However, some of the tumors lacked herpesvirus genomes, suggesting a hit-and-run type oncogenesis. The authors also observed that vaccination could prevent sarcomagenesis in their model.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER; Cre recombinase; herpesvirus; hit-and-run; scenario; mouse model; vaccine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jun 2020 06:08 |
| Last Modified: | 29 Jun 2020 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21440 |
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