Kurtz, Armin (2011) Renin Release: Sites, Mechanisms, and Control. In: UNSPECIFIED Annual Review of Physiology,, 73 . ANNUAL REVIEWS, PALO ALTO, pp. 377-399. ISBN 978-0-8243-0373-0
Full text not available from this repository. (Request a copy)Abstract
In the adult organism, systemically circulating renin almost exclusively originates from the juxtaglomerular cells in the afferent arterioles of the kidneys. These cells share similarities with pericytes and myofibroblasts. They store renin in a vesicular network and granules and release it in a regulated fashion. The release mode of renin is not understood; in particular, the involvement of SNARE proteins is unknown. Renin release is acutely increased via the cAMP signaling pathway, which is triggered mainly by catecholamines and other G(s)-coupled agonists, and is inhibited by calcium-related pathways that are commonly activated by vasoconstrictors. Renin release from juxtaglomerular cells is directly modulated in an inverse fashion by the blood pressure inside the afferent arterioles and by the chloride content in the tubule fluid at the macula densa segment of the distal tubule. Renin release is stimulated by nitric oxide and by prostanoids released by neighboring endothelial and macula densa cells. Steady-state renin concentrations in the plasma are determined essentially by the number of renin-producing cells in the afferent arterioles, which changes in parallel with challenges to the renin-angiotensin-aldosterone system.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | RAT JUXTAGLOMERULAR CELLS; ISOLATED-PERFUSED KIDNEY; MACULA DENSA CELLS; ATRIAL-NATRIURETIC-PEPTIDE; SUCCINATE RECEPTOR GPR91; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE CELLS; ANGIOTENSIN-II; AFFERENT ARTERIOLES; SECRETORY GRANULES; juxtaglomerular cell; secretion; RAAS |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2020 10:13 |
| Last Modified: | 22 Jul 2020 10:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21486 |
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