Huber, Christophe and Marschallinger, Julia and Tempfer, Herbert and Furtner, Tanja and Couillard-Despres, Sebastien and Bauer, Hans-Christian and Rivera, Francisco J. and Aigner, Ludwig (2011) Inhibition of Leukotriene Receptors Boosts Neural Progenitor Proliferation. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 28 (5). pp. 793-804. ISSN 1015-8987,
Full text not available from this repository. (Request a copy)Abstract
Neural stem and progenitor cells serve as a reservoir for new neurons in the adult brain throughout lifetime. One of the critical steps determining the net production of new neurons is neural progenitor proliferation, which needs to be tightly controlled. Since inflammation has detrimental effects on neurogenesis and the 5-lipoxygenase/leukotriene pathway is involved in inflammatory processes, we investigated the effects of leukotrienes and montelukast, a small molecule inhibitor of the leukotriene receptors CysLT 1 R and GPR17, on neural stem and progenitor cell proliferation. We demonstrate expression of the leukotriene receptor GPR17 by neural progenitors and by neural stem cells. Stimulation with excess amounts of leukotrienes did not affect progenitor proliferation, whereas blockade of GPR17 with montelukast strongly elevated neural stem and progenitor proliferation, while maintaining their differentiation fate and potential. This effect was associated with increased ERK1/2 phosphorylation suggesting an involvement of the EGF signaling cascade. Based on our results, montelukast and the inhibition of the 5-LOX pathway might be potent candidates for future therapies employing neurogenesis to promote structural and functional improvement in neurodegeneration, neuropsychiatric disease and ageing. Copyright (C) 2011 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOCAL CEREBRAL-ISCHEMIA; ADULT HIPPOCAMPAL NEUROGENESIS; AGE-RELATED DECREASE; KAPPA-B ACTIVATION; RAT DENTATE GYRUS; 5-LIPOXYGENASE EXPRESSION; CELL-PROLIFERATION; PUTATIVE ROLE; ANIMAL-MODEL; MOUSE MODEL; Neurogenesis; Neural progenitors; Differentiation; Leukotriene; MAP kinase pathway |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jun 2020 12:15 |
| Last Modified: | 29 Jun 2020 12:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21504 |
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