Bosserhoff, Anja and Hellerbrand, Claus (2011) Obesity and Fatty Liver Are 'Grease' for the Machinery of Hepatic Fibrosis. DIGESTIVE DISEASES, 29 (4). pp. 377-383. ISSN 0257-2753,
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Nonalcoholic fatty liver disease (NAFLD) starts with hepatic steatosis, which can progress with inflammation to nonalcoholic steatohepatitis, and a subset of patients develop progressive fibrosis and ultimately cirrhosis. In the majority of cases, NAFLD is associated with (components of) the metabolic syndrome. Obesity, diabetes and hepatic steatosis are also independent risk factors for hepatic fibrosis in different chronic liver diseases. However, the question is whether it is actually nonalcoholic steatohepatitis and not 'simple' steatosis that promotes fibrosis progression based on hepatocellular injury. In this review, the concept will be put forward that (1) hepatic steatosis per se is profibrogenic, and (2) that in NAFLD development and progression of hepatic fibrosis is not simply determined by (the degree of) hepatic inflammation. In addition to the liver, this view is expanded to other organs affected by the metabolic syndrome, which affects hepatic injury and fibrosis also via extrahepatic pathophysiological alterations. In conclusion, fatty liver and the metabolic syndrome, respectively, have to be recognized as significant lubricants of hepatic fibrosis, and simple hepatic steatosis cannot be considered as benign. Copyright (C) 2011 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TISSUE GROWTH-FACTOR; IDIOPATHIC PULMONARY-FIBROSIS; OBSTRUCTIVE SLEEP-APNEA; NONALCOHOLIC STEATOHEPATITIS; STELLATE CELLS; HIGH GLUCOSE; INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; DIABETES-MELLITUS; GUT MICROBIOME; Hepatic fibrosis; Hepatic steatosis; Nonalcoholic fatty liver disease; Metabolic syndrome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jun 2020 07:13 |
| Last Modified: | 30 Jun 2020 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21561 |
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