Schnabl, Bernd and Czech, Barbara and Valletta, Daniela and Weiss, Thomas S. and Kirovski, Georgi and Hellerbrand, Claus (2011) Increased expression of Zinc finger protein 267 in non-alcoholic fatty liver disease. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 4 (7). pp. 661-666. ISSN 1936-2625,
Full text not available from this repository. (Request a copy)Abstract
Hepatocellular lipid accumulation is a hallmark of non-alcoholic fatty liver disease (NAFLD), which encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and ultimately cirrhosis. Zinc finger protein 267 (ZNF267) belongs to the family of Kruppel-like transcription factors, which regulate diverse biological processes that include development, proliferation, and differentiation. We have previously demonstrated that ZNF267 expression is up-regulated in liver cirrhosis and is further increased in hepatocellular carcinoma (HCC). Here, we analyzed the expression of ZNF267 in tissue specimens of NAFLD patients and found a significant up-regulation compared to normal liver tissue. Noteworthy, ZNF267 mRNA was already significantly increased in steatotic liver tissue without inflammation. In line with this, incubation of primary human hepatocytes with palmitic acid induced a dose-dependent lipid accumulation and corresponding dose-dependent ZNF267 induction in vitro. Furthermore, hepatocellular lipid accumulation induced formation of reactive oxygen species (ROS), and also chemically induced ROS formation increased ZNF267 mRNA expression. In summary with previous findings, which revealed ZNF267 as pro-fibrogenic and pro-cancerogenic factor in chronic liver disease, the present study further suggests ZNF267 as promising therapeutic target particularly for NAFLD patients. In addition, it further indicates that hepatic steatosis per se has pathophysiological relevance and should not be considered as benign.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC STELLATE CELLS; DE-NOVO LIPOGENESIS; HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; OXIDATIVE STRESS; NATURAL-HISTORY; GROWTH-FACTOR; UP-REGULATION; HEPATOCYTES; STEATOSIS; Non-alcoholic fatty liver disease; Kruppel-like factor; ZNF267 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jun 2020 11:22 |
| Last Modified: | 30 Jun 2020 11:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21596 |
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