Shafirstein, Gal and Moreno, Mauricio and Klein, Annette and Siegel, Eric and Babilas, Philipp and Landthaler, Michael and Baeumler, Wolfgang (2011) Treatment of leg veins with indocyanine green and lasers investigated with mathematical modelling. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 27 (8). pp. 771-781. ISSN 0265-6736, 1464-5157
Full text not available from this repository. (Request a copy)Abstract
Purpose: The treatment of leg veins is routinely performed in clinical practice using near infrared (NIR) lasers. However, due to low absorption of NIR light in blood vessels, the clinical results are still suboptimal. The absorption of the NIR light can be significantly increased with intravenous introduction of an indocyanine green (ICG) dye. In this work a mathematical model was used to delineate clinically valid settings for ICG and NIR lasers for the treatment of leg veins. Methods: A finite element commercial package was used to simulate light propagation and absorption and heat generation in a skin-like geometry. The simulations were conducted for 755nm and 810nm light wavelengths, which are emitted by alexandrite and diode lasers, respectively. Five different laser settings, six different vessel diameters (0.1-2mm) and three ICG concentrations (0, 1 or 2 mg/kg body weight (BW)) were used to calculate the temperature field spatial distribution as a function of time. Results: The diameter of the blood vessels affects the temperature distribution during and following laser irradiation, with and without ICG. Adding 1 or 2 mg/kg bw of ICG will cause significant temperature increase (15-35 degrees C, p <= 0.001) in blood vessels with a diameter of 0.1-1mm and steep temperature gradients in 1.5-2mm diameter blood vessels. Conclusions: Intravenous application of ICG at 1-2 mg/kg may improve coagulation of blood vessels with 0.1-1mm diameter irradiated with either a diode or alexandrite laser. This should be confirmed with clinical trials in the near future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PORT-WINE STAINS; ND-YAG LASER; PULSED DYE-LASER; SKIN BLOOD-FLOW; 1064 NM; SELECTIVE PHOTOTHERMOLYSIS; RETICULAR VEINS; DIFFUSION-APPROXIMATION; VASCULAR MALFORMATIONS; DIODE-LASER; Indocyanine green; ICG; laser; leg veins; mathematical model; selective photothermolysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jul 2020 06:04 |
| Last Modified: | 02 Jul 2020 06:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21598 |
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