Tailoring drug release profile of low-molecular-weight hydrogels by supramolecular co-assembly and thiol-ene orthogonal coupling

Diaz Diaz, David and Morin, Emmanuelle and Schoen, Eva M. and Budin, Ghyslain and Wagner, Alain and Remy, Jean-Serge (2011) Tailoring drug release profile of low-molecular-weight hydrogels by supramolecular co-assembly and thiol-ene orthogonal coupling. JOURNAL OF MATERIALS CHEMISTRY, 21 (3). pp. 641-644. ISSN 0959-9428,

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Abstract

We describe a general user-friendly platform for fine-tuning the drug release properties of low-molecular-weight hydrogels by a combination of supramolecular co-assembly of complementary molecular structures and controlled photochemical thiol-ene cross-linking. Other critical features such as thermomechanical stability and morphology of the nanostructured hydrogels are also tailored by this approach.

Item Type: Article
Uncontrolled Keywords: SELF-ASSEMBLED HYDROGEL; CLICK CHEMISTRY; AMINO-ACID; TERMINAL ALKYNES; GEL; CYCLOADDITION; DERIVATIVES; ENTRAPMENT; ORGANOGELS; DIPEPTIDE;
Subjects: 500 Science > 540 Chemistry & allied sciences
Divisions: Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz
Depositing User: Dr. Gernot Deinzer
Date Deposited: 01 Jul 2020 05:36
Last Modified: 01 Jul 2020 05:36
URI: https://pred.uni-regensburg.de/id/eprint/21615

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