Hullard-Pulstinger, Annette and Holler, Ernst and Hahn, Joachim and Andreesen, Reinhard and Krause, Stefan W. (2011) Prophylactic Application of Nebulized Liposomal Amphotericin B in Hematologic Patients with Neutropenia. ONKOLOGIE, 34 (5). pp. 254-258. ISSN 0378-584X,
Full text not available from this repository.Abstract
Background: Pulmonary invasive fungal infections (IFI) are well-recognized complications with high morbiditiy and mortality in patients with hematologic malignancies. Patients and Methods: Aerosolized liposomal amphotericin B (lipAmB) was evaluated as an antifungal prophylaxis in patients with an expected neutropenia of more than 10 days due to intensive chemotherapy or stem cell transplantation, in a prospective phase II trial. Results: 98 treatment episodes were included in the study and compared to 105 historical control patients. Inhalation was performed between 0 and 103 days. No severe side effects of therapy occurred. 40 patients considered inhalations as unpleasant, 2 as very unpleasant, mostly due to bad taste or cough. Few cases of definite or probable IFI were recorded, whereas a large number of patients were treated with systemic antifungal therapy for pneumonia or fever of unknown origin without a significant difference between study patients and controls. In a predefined subgroup analysis of 48 patients with newly diagnosed acute myeloid leukemia (AML), significantly more patients survived for 1 year in the AmB prophylaxis than in the control group (80% vs. 54%, p < 0.01). Conclusions: Inhalations of lipAmB are feasible and safe. Results in the subgroup of patients with AML together with data from other trials suggest further evaluation of effectiveness.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INVASIVE PULMONARY ASPERGILLOSIS; RANDOMIZED MULTICENTER TRIAL; PROLONGED NEUTROPENIA; FUNGAL-INFECTIONS; LIPID COMPLEX; EFFICACY; EPIDEMIOLOGY; DEOXYCHOLATE; CANCER; RATS; Amphotericin; Antifungal agents; Antibiotic prophylaxis; Neutropenia; Inhalation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Jul 2020 08:43 |
| Last Modified: | 01 Jul 2020 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21642 |
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