Nuhn, Philipp and Bastian, Patrick J. and Novara, Giacomo and Svatek, Robert S. and Karakiewicz, Pierre I. and Skinner, Eila and Fradet, Yves and Izawa, Jonathan I. and Kassouf, Wassim and Montorsi, Francesco and Mueller, Stefan C. and Fritsche, Hans-Martin and Sonpavde, Guru and Tilki, Derya and Isbarn, Hendrik and Ficarra, Vincenzo and Dinney, Colin P. and Shariat, Shahrokh F. (2011) Concomitant Carcinoma in situ in Cystectomy Specimens Is Not Associated with Clinical Outcomes after Surgery. UROLOGIA INTERNATIONALIS, 87 (1). pp. 42-48. ISSN 0042-1138,
Full text not available from this repository. (Request a copy)Abstract
Objective: The aim of this study was to externally validate the prognostic value of concomitant urothelial carcinoma in situ (CIS) in radical cystectomy (RC) specimens using a large international cohort of bladder cancer patients. Methods: The records of 3,973 patients treated with RC and bilateral lymphadenectomy for urothelial carcinoma of the bladder (UCB) at nine centers worldwide were reviewed. Surgical specimens were evaluated by a genitourinary pathologist at each center. Uni- and multivariable Cox regression models addressed time to recurrence and cancer-specific mortality after RC. Results: 1,741 (43.8%) patients had concomitant CIS in their RC specimens. Concomitant CIS was more common in organ-confined UCB and was associated with lymphovascular invasion (p < 0.001). Concomitant CIS was not associated with either disease recurrence or cancer-specific death regardless of pathologic stage. The presence of concomitant CIS did not improve the predictive accuracy of standard predictors for either disease recurrence or cancer-specific death in any of the subgroups. Conclusions: We could not confirm the prognostic value of concomitant CIS in RC specimens. This, together with the discrepancy between pathologists in determining the presence of concomitant CIS at the morphologic level, limits the clinical utility of concomitant CIS in RC specimens for clinical decision-making. Copyright (C) 2011 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; RADICAL CYSTECTOMY; BLADDER-CANCER; URINARY-BLADDER; PROGRESSION; EXPRESSION; RISK; INVOLVEMENT; ALLELOTYPE; RECURRENCE; Carcinoma in situ; Radical cystectomy, prognosis; Bladder cancer; Urothelial carcinoma, survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jul 2020 12:52 |
| Last Modified: | 02 Jul 2020 12:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21703 |
Actions (login required)
 |
View Item |
