Benseler, V. and Schlitt, H. J. (2011) The Liver as an Immunological Organ. ZEITSCHRIFT FUR GASTROENTEROLOGIE, 49 (1). pp. 54-62. ISSN 0044-2771
Full text not available from this repository. (Request a copy)Abstract
In many species, liver transplants induce antigen-specific immunological tolerance. Furthermore, the liver seems to play an important role in oral tolerance although the exact mechanisms as to how the liver induces immunological tolerance still need to be defined. Apart from the presence of an unusual subset of effector cells of the innate immune system, the liver is rich in CD8+ T cells with an activated and preapoptotic phenotype. In this article, we discuss the suggested hypothesis to explain this phenotype. In addition, we discuss the different cell types that have been suggested to serve as antigen-presenting cells (APC) for naive T cells. Interestingly, different APCs seem to use different mechanisms to induce tolerance while hepatic stellate cells were reported to induce an effective immune response.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SINUSOIDAL-ENDOTHELIAL-CELLS; CD8(+) T-CELLS; NATURAL-KILLER-CELL; HEPATIC STELLATE CELLS; KUPFFER CELLS; DENDRITIC CELLS; TOLERANCE INDUCTION; ORAL TOLERANCE; IN-VIVO; ALLOGRAFT REJECTION; liver; T cells; tolerance |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 22 Apr 2020 06:32 |
| Last Modified: | 22 Apr 2020 06:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/21712 |
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