Schaedler, Stephanie and Krause, Janis and Himmelsbach, Kiyoshi and Carvajal-Yepes, Monica and Lieder, Franziska and Klingel, Karin and Nassal, Michael and Weiss, Thomas S. and Werner, Sabine and Hildt, Eberhard (2010) Hepatitis B Virus Induces Expression of Antioxidant Response Element-regulated Genes by Activation of Nrf2. JOURNAL OF BIOLOGICAL CHEMISTRY, 285 (52). pp. 41074-41086. ISSN 0021-9258, 1083-351X
Full text not available from this repository. (Request a copy)Abstract
The expression of a variety of cytoprotective genes is regulated by short cis-acting elements in their promoters, called antioxidant response elements (AREs). A central regulator of ARE-mediated gene expression is the NF-E2-related factor 2 (Nrf2). Human hepatitis B virus (HBV) induces a strong activation of Nrf2/ARE-regulated genes in vitro and in vivo. This is triggered by the HBV-regulatory proteins (HBx and LHBs) via c-Raf and MEK. The Nrf2/ARE-mediated induction of cytoprotective genes by HBV results in a better protection of HBV-positive cells against oxidative damage as compared with control cells. Furthermore, there is a significantly increased expression of the Nrf2/ARE-regulated proteasomal subunit PSMB5 in HBV-positive cells that is associated with a decreased level of the immunoproteasome subunit PSMB5i. In accordance with this finding, HBV-positive cells display a higher constitutive proteasome activity and a decreased activity of the immunoproteasome as compared with control cells even after interferon alpha/gamma treatment. The HBV-dependent induction of Nrf2/ARE-regulated genes might ensure survival of the infected cell, shape the immune response to HBV, and thereby promote establishment of the infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LARGE SURFACE PROTEIN; TRANSGENIC MICE; HBX PROTEIN; LIVER-REGENERATION; HUMAN HEPATOCYTES; X PROTEIN; IN-VITRO; HEPATOCELLULAR-CARCINOMA; HEPATOTROPHIC FACTOR; PROTEASOME COMPLEX; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2020 06:25 |
| Last Modified: | 06 Jul 2020 06:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23725 |
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