Wolff, Daniel and Gerbitz, Armin and Ayuk, Francis and Kiani, Alexander and Hildebrandt, Gerhard C. and Vogelsang, Georgia B. and Elad, Sharon and Lawitschka, Anita and Socie, Gerard and Pavletic, Steven Z. and Holler, Ernst and Greinix, Hildegard (2010) Consensus Conference on Clinical Practice in Chronic Graft-versus-Host Disease (GVHD): First-Line and Topical Treatment of Chronic GVHD. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 16 (12). pp. 1611-1628. ISSN 1083-8791, 1523-6536
Full text not available from this repository.Abstract
Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation is still associated with significant morbidity and mortality First-line treatment of cGVHD is based on steroids of I mg/kg/day of prednisone The role of calcineurin inhibitors remains controversial especially in patients with low risk for mortality (normal platelets counts) whereas patients with low platelets at diagnosis and/or high risk for steroid toxicity may be treated upfront with the combination of prednisone and a calcineurin inhibitor Additional systemic immuno uppressive agents like thalidomide mycophenolic acid and azathio prine failed to improve treatment results in the primary treatment of cGVHD and are in part associated with higher morbidity and in the case of azathioprine with higher mortality Despite advances in diagnosis of cGVHD as well as supportive care half of the patients fail to achieve a long lasting response to first line treatment and infectious morbidity continues to be significant Therefore immunomodulatory interventions with low infectious morbidity and mortality such as photopheresis need urgent evaluation in clinical trials Beside systemic immunosuppression the use of topical immunosuppressive interventions may improve local response rates and may be used as the only treatment in mild localized organ manifestations of cGVHD Biol Blood Marrow Transplant 16 1611-1028 (2010) (C) 2010 American Society for Blood and Marrow Transplantation
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; WORKING GROUP-REPORT; ORAL BECLOMETHASONE DIPROPIONATE; OBSTRUCTIVE AIRWAY DISEASE; ALTERNATE-DAY PREDNISONE; DEVELOPMENT PROJECT; EXTRACORPOREAL PHOTOCHEMOTHERAPY; LICHEN-PLANUS; PUVA THERAPY; Allogeneic hematopoietic stem cell transplantation; Graft-versus-host disease; Immunosuppressive therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2020 07:01 |
| Last Modified: | 06 Jul 2020 07:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23774 |
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