Lehle, Karla and Straub, Rainer H. and Morawietz, Henning and Kunz-Schughart, Leoni A. (2010) Relevance of disease- and organ-specific endothelial cells for in vitro research. CELL BIOLOGY INTERNATIONAL, 34 (12). pp. 1231-1238. ISSN 1065-6995
Full text not available from this repository. (Request a copy)Abstract
The endothelium is a dynamic, heterogeneous, disseminated organ that possesses vital secretory, synthetic, metabolic and immunological functions. Endothelial dysfunction has been implicated as a key factor in the development of organ-specific vascular diseases. This minireview gives a brief overview on EC (endothelial cell) biomarkers in arterial and venous endothelium and critically discusses the different sources of ECs that are most frequently applied in in vitro assays and research. The relevance of organ- and disease-specific endothelial cell cultures for studying cellular responses as a basis for improving therapeutic interventions is highlighted with particular emphasis on endothelial dysfunction in transplant-associated coronary artery disease, in atherosclerotic lesions and in response to diabetes mellitus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STRONG FAMILY-HISTORY; GROWTH-FACTOR-I; PHENOTYPIC HETEROGENEITY; ADHESION MOLECULE-1; DIABETES-MELLITUS; BINDING-PROTEINS; VASCULAR BEDS; HIGH GLUCOSE; COUP-TFII; EXPRESSION; artery; disease; endothelial cell; endothelial progenitor cell; vein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2020 11:10 |
| Last Modified: | 21 Apr 2020 11:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23777 |
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