Kees, Martin G. and Hilpert, Justus W. and Gnewuch, Carsten and Kees, Frieder and Voegeler, Stephan (2010) Clearance of vancomycin during continuous infusion in Intensive Care Unit patients: correlation with measured and estimated creatinine clearance and serum cystatin C. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 36 (6). pp. 545-548. ISSN 0924-8579,
Full text not available from this repository. (Request a copy)Abstract
Vancomycin (VAN) dosing requires adjustment to renal function, which is often estimated using the Cockcroft-Gault formula; however, its precision is poor in Intensive Care Unit (ICU) patients. VAN clearance (CL(Van)) during continuous infusion was prospectively determined in 25 ICU patients [14 male, 11 female; age range 31-82 years; body mass index (BMI) 16.5-41.5 kg/m(2); Acute Physiology and Chronic Health Evaluation (APACHE) II score at admission 8-36; creatinine clearance 25-195 mL/min] and its correlation with measured creatinine clearance (CL(Crea)), estimated creatinine clearance using the Cockcroft-Gault formula (CL(CG)) and estimated glomerular filtration rate according to Hoek's formula based on serum cystatin C (GFR(Hoek)) was investigated. The correlation between CL(Van) and CL(Crea) was very good (r(2) = 0.88), but it was rather poor with CLCG (r(2) = 0.37) and was acceptable with GFR(Hoek) (r(2) = 0.70). For VAN dose adjustments in ICU patients, determination of cystatin C may be an interesting and practical alternative to measured CL(Crea), whereas the Cockcroft-Gault formula should be used with caution. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CRITICALLY-ILL PATIENTS; RENAL-FUNCTION; INTERMITTENT INFUSION; STEADY-STATE; PHARMACOKINETICS; COCKCROFT; FORMULA; 2-HOUR; MARKER; GAULT; HPLC; Pharmacokinetics; ICU; Cystatin C; Creatinine clearance; Dosing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2020 08:32 |
| Last Modified: | 06 Jul 2020 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23799 |
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