Yoshii, Taishi and Hermann, Christiane and Helfrich-Forster, Charlotte (2010) Cryptochrome-Positive and -Negative Clock Neurons in Drosophila Entrain Differentially to Light and Temperature. JOURNAL OF BIOLOGICAL RHYTHMS, 25 (6). pp. 387-398. ISSN 0748-7304,
Full text not available from this repository.Abstract
The blue-light photoreceptive protein Cryptochrome (CRY) plays an important role in the light synchronization of the Drosophila circadian clock Previously, we found that among the approximately 150 clock neurons, many but not all neurons express CRY We speculated that the CRY-positive pacemaker neurons may be especially important for light entrainment, whereas the CRY-negative neurons may be important for other environmental cues, for example, temperature To investigate this hypothesis, we tested the entrainability of the clock neurons to out-of-phase light and temperature cycles When light-dark or light-dim light cycles were shifted by 12 h with respect to temperature cycles, behavioral rhythms of wild-type flies were re-entrained by the light cycles In this condition, we found that TIMELESS (TIM) level was strongly influenced by the temperature cycles in many CRY-negative clock neurons, suggesting that the CRY-negative neurons have higher sensitivity to temperature Under the same conditions, cry-null mutants entrained to the temperature cycles or very slowly re-entrained to light-dark cycles Our results suggest that there are 2 types of clock neurons having differential sensitivities to light and temperature, and CRY is a key component for the preferential entrainment to light
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCADIAN CLOCK; FRUIT-FLIES; PACEMAKER NEURONS; ENDOGENOUS CLOCK; COMPOUND EYES; BRAIN; MELANOGASTER; RHYTHMS; PDF; SYNCHRONIZATION; Cryptochrome; temperature cycle; timeless; locomotor activity; immunohistochemistry moonlight |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2020 08:36 |
| Last Modified: | 06 Jul 2020 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23803 |
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