Beier, F. and Kittan, N. and Holzmann, T. and Schardt, K. and Andreesen, R. and Holler, E. and Hildebrandt, G. C. (2010) Successful treatment of Scedosporium apiospermum soft tissue abscess with caspofungin and voriconazole in a severely immunocompromised patient with acute myeloid leukemia. TRANSPLANT INFECTIOUS DISEASE, 12 (6). pp. 538-542. ISSN 1398-2273, 1399-3062
Full text not available from this repository. (Request a copy)Abstract
P>We report the case of a 53-year-old female patient with refractory acute myeloid leukemia developing a necrotic, soft tissue abscess on the right forearm caused by Scedosporium apiospermum during prolonged severe neutropenia (absolute white blood cell count < 500/mu L for 49 days). In the context of the severely immunocompromised state of the patient and her need for allogeneic hematopoietic stem cell transplantation (HSCT), surgical treatment options were not favored. Therefore, combined antifungal therapy with voriconazole and caspofungin was started, based on the results of the in vitro testing (minimum inhibitory concentrations of voriconazole, posaconazole, and amphotericin B: 1, 4, and > 2 mg/L, respectively). The local site of infection slowly improved clinically and no spread of S. apiospermum infection to other sites was observed. After HSCT, the soft tissue abscess resolved completely and the patient has remained free of S. apiospermum infection since then. We successfully demonstrate that the use of combined antifungal therapy with voriconazole and casopfungin may further improve the clinical course and provides a promising therapeutic option to treat Scedosporium infections in such patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BOYDII SPECIES COMPLEX; PSEUDALLESCHERIA-BOYDII; INFECTION; TRANSPLANTATION; EPIDEMIOLOGY; COMBINATIONS; PROLIFICANS; THERAPY; CANCER; Pseudallescheria boydii; Scedosporium apiospermum; soft tissue abscess; voriconazole; caspofungin; allogeneic stem cell transplantation; combination therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 05:01 |
| Last Modified: | 07 Jul 2020 05:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23839 |
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