Klotz, T. and Mathers, M. J. and Gerken, M. and Klinkhammer-Schalke, M. and Hofstaedter, F. (2010) Social gradient of PSA screening? 8 years follow up from the cancer registry of the tumor center in Regensburg. UROLOGE, 49 (12). pp. 1503-1507. ISSN 1433-0563,
Full text not available from this repository. (Request a copy)Abstract
Background. Prostate cancer is the most frequent male cancer. In Germany most tumors are detected by PSA testing. Data on the long-term survival of patients with localized early prostate carcinoma are insufficient. We examined the relative survival of the patients with organ-defined prostate cancer (TNM T1-2N0M0, UICC I-II) compared to the standardized age-adjusted rates of the normal male population. Methods. Epidemiological and clinical data from 4,124 patients with prostate cancer diagnosed from 1998 to 2007 were extracted from the cancer registry of the tumor center in Regensburg; 2,087 patients suffered from localized early cancer. Kaplan-Meier analysis was used to estimate the overall survival rates in the patient cohorts irrespective of primary cancer therapy. These rates were adjusted for the expected survival rates in a comparable set of individuals from the general population. Results. Eight years after diagnosis, patients with stage I and II localized prostate cancer had an approximately 10% relative increase in survival compared with the normal male population. This relative increase in survival was already observed 3 years after diagnosis. Conclusion. Patients with stage I-II localized prostate cancer have improved survival compared with the normal male population. This finding cannot be explained solely by the administration of prostate cancer treatments, which do not affect survival until 8-10 years after treatment, suggesting that men who participate in PSA testing may have a better overall health status. Another hypothesis may be a social gradient of PSA testing in Germany.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROSTATE-CANCER; Prostate cancer; Outcomes research; Health status; Social gradient of prevention; PSA |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 05:03 |
| Last Modified: | 07 Jul 2020 05:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23842 |
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