Aguilar, Ana Laura Gutierrez and Piskol, Robert and Beitzinger, Michaela and Zhu, Jia Yun and Kruspe, Dagmar and Aszodi, Attila and Moser, Markus and Englert, Christoph and Meister, Gunter (2010) The small RNA expression profile of the developing murine urinary and reproductive systems. FEBS LETTERS, 584 (21). pp. 4426-4434. ISSN 1873-3468,
Full text not available from this repository. (Request a copy)Abstract
microRNAs (miRNAs) are small non-coding RNAs with fundamental roles in the regulation of gene expression. miRNAs assemble with Argonaute (Ago) proteins to miRNA-protein complexes (miRNPs), which interact with distinct binding sites on mRNAs and regulate gene expression. Specific miRNAs are key regulators of tissue and organ development and it has been shown in mammals that miRNAs are also involved in the pathogenesis of many diseases including cancer. Here, we have characterized the miRNA expression profile of the developing murine genitourinary system. Using a computational approach, we have identified several miRNAs that are specific for the analyzed tissues or the developmental stage. Our comprehensive miRNA expression atlas of the developing genitourinary system forms an invaluable basis for further functional in vivo studies. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KIDNEY DEVELOPMENT; MICRORNAS; MECHANISMS; MIRNAS; TRANSLATION; REPRESSION; RESOURCE; TARGETS; microRNA; Kidney; Testis; Ovary; Gene silencing |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2020 12:56 |
| Last Modified: | 06 Jul 2020 12:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23888 |
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