Park, Yikyung and Spiegelman, Donna and Hunter, David J. and Albanes, Demetrius and Bergkvist, Leif and Buring, Julie E. and Freudenheim, Jo L. and Giovannucci, Edward and Goldbohm, R. Alexandra and Harnack, Lisa and Kato, Ikuko and Krogh, Vittorio and Leitzmann, Michael F. and Limburg, Paul J. and Marshall, James R. and McCullough, Marjorie L. and Miller, Anthony B. and Rohan, Thomas E. and Schatzkin, Arthur and Shore, Roy and Sieri, Sabina and Stampfer, Meir J. and Virtamo, Jarmo and Weijenberg, Matty and Willett, Walter C. and Wolk, Alicja and Zhang, Shumin M. and Smith-Warner, Stephanie A. (2010) Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. CANCER CAUSES & CONTROL, 21 (11). pp. 1745-1757. ISSN 0957-5243, 1573-7225
Full text not available from this repository. (Request a copy)Abstract
To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, > 4,000 vs. a parts per thousand currency sign1,000 mu g/day) for vitamin A, 0.81 (0.71-0.92, > 600 vs. a parts per thousand currency sign100 mg/day) for vitamin C, and 0.78 (0.66-0.92, > 200 vs. a parts per thousand currency sign6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOOD FREQUENCY QUESTIONNAIRE; RANDOMIZED CONTROLLED-TRIAL; SERUM ALPHA-TOCOPHEROL; COLORECTAL-CANCER; WOMENS HEALTH; BETA-CAROTENE; DIETARY ASSESSMENT; MULTIVITAMIN USE; DISEASE PREVENTION; UNITED-STATES; Vitamin A; Vitamin C; Vitamin E; Multivitamin; Colon cancer; Cohort study; Pooled analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 06:26 |
| Last Modified: | 07 Jul 2020 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23918 |
Actions (login required)
 |
View Item |
