Springwald, Anette and Lattrich, Claus and Skrzypczak, Maciej and Goerse, Regina and Ortmann, Olaf and Treeck, Oliver (2010) Icb-1 Gene Expression is Elevated in Human Endometrial Adenocarcinoma and is Closely Associated With HER2 Expression. CANCER INVESTIGATION, 28 (9). pp. 904-909. ISSN 0735-7907, 1532-4192
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Human gene icb-1 (C1orf38) has been initially cloned by our group from endometrial adenocarcinoma cells. In this study, we examined icb-1 expression in 90 endometrial cancer and normal endometrial tissue specimens. Expression of icb-1 was significantly (about 3.5-fold) higher in endometrial cancer than in normal endometrium (p <.0001). Determination of various molecular markers revealed that only Ki-67 expression differed between both groups in a similarly significant manner. Furthermore, we observed a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of icb-1 in endometrial cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER CELL-LINES; STEROID-RECEPTORS; POSITIVE SELECTION; KI-67 EXPRESSION; CARCINOMA; BREAST; DIFFERENTIATION; PROTEIN; OVARIAN; MARKER; Icb-1 gene; C1orf38; Endometrial cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 06:30 |
| Last Modified: | 07 Jul 2020 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23920 |
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