Jorgensen, P. and Poethko-Mueller, C. and Hellenbrand, W. and Jilg, W. and Thierfelder, W. and Meyer, C. and An Der Heiden, M. and Schlaud, M. and Radun, D. (2010) Low hepatitis B immunogenicity of a hexavalent vaccine widely used in Germany: results of the German Health Survey for Children and Adolescents, 2003-2006. EPIDEMIOLOGY AND INFECTION, 138 (11). pp. 1621-1629. ISSN 0950-2688,
Full text not available from this repository. (Request a copy)Abstract
The success of childhood vaccination against hepatitis B relies on persistence of immunity into adolescence and adulthood. In 2000, two hexavalent vaccines with a hepatitis B component (Hexavac (R), Infanrix hexa (R)) were introduced in Germany. Hexavac was withdrawn in 2005 amidst concerns about its long-term hepatitis B protection. We compared hepatitis B surface antibody (anti-HBs) levels in children fully vaccinated with Hexavac or Infanrix hexa (n=477) in a secondary data analysis of a large cross-sectional health survey in Germany. On average 2.4 years after vaccination, 25.3% of Hexavac vaccinees had anti-HBs levels < 10 mIU/ml (95% CI 19.0-32.8) compared to 4.7% of Infanrix hexa vaccinees (95% CI 2.4-8.9). These findings suggest that short-term hepatitis B immunogenicity in Hexavac vaccinees may also be weaker. Further studies are warranted to assess whether Hexavac vaccinees should be re-vaccinated or receive a booster vaccination before these birth cohorts reach adolescence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLUENZAE TYPE-B; LONG-TERM IMMUNOGENICITY; PNEUMOCOCCAL CONJUGATE VACCINE; ACELLULAR PERTUSSIS; FOLLOW-UP; INACTIVATED POLIOVIRUS; COMBINATION VACCINE; CELL MEMORY; T-CELL; PERSISTENCE; Hepatitis B; public health; vaccination (immunization); vaccines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 06:44 |
| Last Modified: | 07 Jul 2020 06:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23927 |
Actions (login required)
 |
View Item |
