Kwok, Pingling and Gleich, Otto and Huebner, Gerhard and Strutz, Juergen (2010) PROGNOSTIC IMPORTANCE OF "CLEAR VERSUS REVISED MARGINS" IN ORAL AND PHARYNGEAL CANCER. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 32 (11). pp. 1479-1484. ISSN 1043-3074,
Full text not available from this repository. (Request a copy)Abstract
Background. Opinions differ regarding the usefulness of accurate, but costly, frozen sections. Most physicians believe that negative margins are essential for the prognosis of patients with oral and pharyngeal cancer. We examined whether immediate repeated resections in patients with positive margins, based on findings from frozen sections, resulted in improved patient survival. Methods. Data from 417 patients identified with cancer of the pharynx and floor of the mouth were analyzed retrospectively. Results. The 5-year survival rate for R0 and R1-R0 groups was 72% to 76% and was significantly better (p <= .034) than that for R1 and R2 groups (58%, 40%). Despite clear margins, large tumors had a poorer prognosis than that of small tumors. Conclusions. Patients receiving repeated resection had the same survival rate as patients who had the tumor resected immediately with negative margins. The use of frozen sections yields a benefit for 15.6% of the operated patients and increases the overall 5-year survival rate by 2% to 3%. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1479-1484, 2010
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; POSITIVE MARGINS; FROZEN-SECTIONS; NECK; HEAD; ACCURACY; CAVITY; MOUTH; FLOOR; SITE; frozen sections; margins; oral cancer; pharyngeal cancer; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 07:10 |
| Last Modified: | 07 Jul 2020 07:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23938 |
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