Dirr, Franziska and Echtenacher, Bernd and Heesemann, Juergen and Hoffmann, Petra and Ebel, Frank and Wagener, Johannes (2010) AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 300 (7). pp. 496-502. ISSN 1438-4221, 1618-0607
Full text not available from this repository. (Request a copy)Abstract
The cell wall integrity (CWI) pathway, best characterized in S. cerevisiae, is strikingly conserved in Aspergillus species. We analyzed the importance of AfMkk2, a CWI signaling kinase, for virulence and antifungal therapy in the human pathogen A. fumigatus. A mutant lacking AfMkk2 is less adherent to glass and plastic surfaces and shows increased sensitivity to alkaline pH stress and antifungals. Rather than AfMpkA, the target kinase of AfMkk2, AfMpkB is activated in the mutant under cell wall stress. Interestingly, the mutant lacking AfMkk2 shows an enhanced sensitivity to posaconazole and voriconazole. And in agreement with its sensitivity to moderate temperatures, it is less virulent in a murine infection model. Our data underline the importance of mkk2 for the fitness, but also for the pathogenicity of A. fumigarus. (C) 2010 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACTIVATED PROTEIN-KINASE; SACCHAROMYCES-CEREVISIAE; POLARIZED GROWTH; FUNGAL CELL; NIDULANS; GENE; PKCA; STRESS; MODEL; MPKA; Cell wall integrity; CWI; Mkk2; Mkk1; MpkA |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 08:37 |
| Last Modified: | 07 Jul 2020 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23946 |
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