Chen, Huixiao and Lohr, Frank and Fritz, Peter and Wenz, Frederik and Dobler, Barbara and Lorenz, Friedlieb and Muehlnickel, Werner (2010) STEREOTACTIC, SINGLE-DOSE IRRADIATION OF LUNG TUMORS: A COMPARISON OF ABSOLUTE DOSE AND DOSE DISTRIBUTION BETWEEN PENCIL BEAM AND MONTE CARLO ALGORITHMS BASED ON ACTUAL PATIENT CT SCANS. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78 (3). pp. 955-963. ISSN 0360-3016, 1879-355X
Full text not available from this repository. (Request a copy)Abstract
Purpose: Dose calculation based on pencil beam (PB) algorithms has its shortcomings predicting dose in tissue heterogeneities. The aim of this study was to compare dose distributions of clinically applied non intensity-modulated radiotherapy 15-MV plans for stereotactic body radiotherapy between voxel Monte Carlo (XVMC) calculation and PB calculation for lung lesions. Methods and Materials: To validate XVMC, one treatment plan was verified in an inhomogeneous thorax phantom with EDR2 film (Eastman Kodak, Rochester, NY). Both measured and calculated (PB and XVMC) dose distributions were compared regarding profiles and isodoses. Then, 35 lung plans originally created for clinical treatment by PB calculation with the Eclipse planning system (Varian Medical Systems, Palo Alto, CA) were recalculated by XVMC (investigational implementation in PrecisePLAN [Elekta AB, Stockholm, Sweden]). Clinically relevant dose volume parameters for target and lung tissue were compared and analyzed statistically. Results: The XVMC calculation agreed well with film measurements (<1% difference in lateral profile), whereas the deviation between PB calculation and film measurements was up to +15%. On analysis of 35 clinical cases, the mean dose, minimal dose and coverage dose value for 95% volume of gross tumor volume were 1.14 +/- 1.72 Gy, 1.68 +/- 1.47 Gy, and 1.24 +/- 1.04 Gy lower by XVMC compared with PB, respectively (prescription dose, 30 Gy). The volume covered by the 9 Gy isodose of lung was 2.73% +/- 3.12% higher when calculated by XVMC compared with PB. The largest differences were observed for small lesions circumferentially encompassed by lung tissue. Conclusions: Pencil beam dose calculation overestimates dose to the tumor and underestimates lung volumes exposed to a given dose consistently for 15-MV photons. The degree of difference between XVMC and PB is tumor size and location dependent. Therefore XVMC calculation is helpful to further optimize treatment planning. (C) 2010 Elsevier Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTENSITY-MODULATED RADIOTHERAPY; MEDICALLY INOPERABLE PATIENTS; RADIATION-THERAPY; CANCER NSCLC; BODY RADIOTHERAPY; PHOTON; IMRT; MODEL; ACCELERATOR; CONE; Monte Carlo; Pencil beam; Stereotactic body radiotherapy (SBRT); Lung tumor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 08:40 |
| Last Modified: | 07 Jul 2020 08:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23949 |
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