Schwab-Malek, Susanne and Vatankhah, Bijan and Bogdahn, Ulrich and Horn, Markus and Audebert, Heinrich J. (2010) Depressive symptoms and quality of life after thrombolysis in stroke: the TEMPiS study. JOURNAL OF NEUROLOGY, 257 (11). pp. 1848-1854. ISSN 0340-5354, 1432-1459
Full text not available from this repository. (Request a copy)Abstract
Intravenous thrombolysis leads to a reduction of post-stroke disability. No data exist about whether depression and poor quality of life (QoL) remain relevant problems in patients with good functional outcome. We assessed mood and QoL at 3 and 6 months after stroke in consecutive patients who received intravenous thrombolysis in stroke centers and telemedicine hospitals within the TEMPiS network. The Beck Depression Inventory (BDI) was used with BDI >= 18 indicating clinically relevant depressive symptoms. Stroke specific quality of life (SSQOL) was used for QoL assessment with the definition of SSQOL total score < 60% for poor QoL. Associations of BDI and SSQOL with baseline parameters and modified Rankin scale (mRS) in follow-up were analyzed. In patients with known mRS 0-4 at 3 months (N = 213), BDI was available in 74% and SSQOL in 77%. At 3 and 6 months, 23 and 18% of patients had clinically relevant depressive symptoms; 25 and 24% reported a poor QoL. The mRS at 3 months correlated with BDI (r = 0.43, p < 0.01) and SSQOL (r = -0.75, p < 0.01). BDI >= 18 was observed in 11% of patients with mRS 0-1 and 16% in mRS 0-2. Severe stroke (NIHSS >= 12) at admission (OR 1.23, 0.57-2.66; p = 0.57) was not predictive for depressive symptoms but for poor QoL (OR 2.77, 95%CI 1.34-5.74). Depressive symptoms and impaired QoL are observed in a substantial proportion of stroke patients at 3 months after intravenous thrombolysis. Health professionals should be aware that thrombolysed patients may have relevant mood disorders despite good functional outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE ISCHEMIC-STROKE; POSTSTROKE DEPRESSION; LESION LOCATION; FOLLOW-UP; MORTALITY; INFARCTION; FREQUENCY; RISK; CARE; Stroke; Thrombolysis; Outcome; Depression; Quality of life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2020 09:37 |
| Last Modified: | 07 Jul 2020 09:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23958 |
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