Hartl, J. and Buettner, R. and Rockmann, F. and Farkas, S. and Holstege, A. and Vogel, C. and Schnitzbauer, A. and Schlitt, H. J. and Schoelmerich, J. and Kirchner, Gabriele (2010) Giant Cell Hepatitis: an Unusual Cause of Fulminant Liver Failure. ZEITSCHRIFT FUR GASTROENTEROLOGIE, 48 (11). pp. 1293-1296. ISSN 0044-2771, 1439-7803
Full text not available from this repository. (Request a copy)Abstract
Giant cell hepatitis is a very rare disease of unknown origin. It has been hypothesized that drugs, viral infections, or autoimmune reactions may play a pathogenetic role. Here, we describe a 33 year old patient with bacterial bronchitis who was treated with doxycycline (100 mg/d) for one week. Furthermore the patient complained of malaise and a distinct jaundice. Liver parameters increased dramatically (AST 4670 U/l, ALT 5350U/l, bilirubin 226 mu mol/l) and liver function was impaired (INR=1,45). The ultrasound scan showed a hepatomegaly with no signs of cirrhosis, normal spleen size and normal bile ducts; liver perfusion was normal. No evidence of Wilson's disease, hemochromatosis, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis, hepatitis A, B, C and E, HIV, CMV, VZV, adenoviral infections, or paracetamol intoxication was found. Subsequently, the patient developed acute liver failure (AST 2134 U/l, ALT 2820 U/l, bilirubin 380 mu mol/l, INR 3.0) and a beginning renal failure. Therefore, he was transferred to our transplant center. Due to increasing confusion and somnolence due to cerebral edema mechanical ventilation was needed. Because of an acute renal failure and severe hepatic encephalopathia MARS-hemodialysis was performed. Three weeks after the appearance of the jaundice he underwent liver transplantation (MELD 40). Surprisingly, in the explanted liver the diagnosis of giant cell hepatitis was made. Today - 2 years after successful liver transplantation - the patient is in a very good condition with normal liver function. In conclusion, giant cell hepatitis is a rare cause of acute liver failure that is often recognized only histologically.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AUTOIMMUNE HEMOLYTIC-ANEMIA; TRANSPLANTATION; RECURRENT; PATIENT; DOXYCYCLINE; DISEASE; giant cell hepatitis; fulminant liver failure; liver transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jul 2020 05:29 |
| Last Modified: | 08 Jul 2020 05:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/23992 |
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