Buechler, Christa and Wanninger, Josef and Neumeier, Markus (2010) Adiponectin receptor binding proteins - recent advances in elucidating adiponectin signalling pathways. FEBS LETTERS, 584 (20). pp. 4280-4286. ISSN 0014-5793
Full text not available from this repository. (Request a copy)Abstract
Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration and inflammation. Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed. Clathrin-dependent endocytosis of AdipoR1 and adiponectin has been demonstrated to modulate adiponectin bioactivity. Recently, APPL1 has been identified as an AdipoR1 and AdipoR2 binding protein. Furthermore, activated protein kinase C1, endoplasmic reticulum protein 46 and protein kinase CK2 beta subunit form a complex with AdipoR1. This review summarizes recent studies exploiting heterologous expression of adiponectin receptors in yeast, and the type and function of the recently described adiponectin receptor associated proteins. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACTIVATED C-KINASE; MOLECULAR-WEIGHT ADIPONECTIN; HUMAN CEREBROSPINAL-FLUID; PRIMARY HUMAN HEPATOCYTES; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; APOLIPOPROTEIN-B; MUSCLE-CELLS; T-CADHERIN; Adiponectin receptor; APPL; Endocytosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Apr 2020 11:02 |
| Last Modified: | 20 Apr 2020 11:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24000 |
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