Fritsche, Hans-Martin and Burger, Maximilian and Dietmaier, Wolfgang and Denzinger, Stefan and Bach, Ekkehard and Otto, Wolfgang and Doblinger, Matthias and Schwarz, Stephan and Buchner, Hannes and Hartmann, Arndt (2010) Multicolor FISH (UroVysion) Facilitates Follow-up of Patients With High-Grade Urothelial Carcinoma of the Bladder. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 134 (4). pp. 597-603. ISSN 0002-9173,
Full text not available from this repository.Abstract
The aim of the present prospective study was to assess the diagnostic benefit of UroVysion (Vysis-Abbott Laboratories, Downers Grove, IL) in the follow-up of patients with a history of high-grade non-muscle-invasive urothelial carcinoma of the bladder (NMIBC). An unselected cohort of 25 patients with a history of high-grade NMIBC was prospectively followed up by office-based cystoscopy, cytology, and UroVysion in 210 events. The sensitivity and specificity for standard combined cystoscopy and cytology were 78% and 83%, respectively. UroVysion yielded a considerably higher detection rate with 94% and 93%, respectively. In 89% of the follow-up events of patients with a history of previous carcinoma in situ (CIS) and negative cystoscopy but a positive UroVysion finding, CIS recurrence was noticed within 5 months. UroVysion is a worthwhile approach in patients with previous CIS, a high risk for the development of CIS, or previous unequivocal cytology suggestive of CIS, especially during or shortly after instillation therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-SITU HYBRIDIZATION; TRANSITIONAL-CELL CARCINOMA; NEGATIVE URINE CYTOLOGY; VOIDED URINE; INTRAVESICAL THERAPY; CANCER SURVEILLANCE; MULTIPROBE FISH; ASSAY; MULTITARGET; WASHINGS; Bladder; UroVysion; Fluorescence in situ hybridization; FISH; Carcinoma in situ; CIS |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jul 2020 09:27 |
| Last Modified: | 08 Jul 2020 09:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24032 |
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