Bundscherer, Annika and Vogt, Thomas and Koehl, Gudrun and Landthaler, Michael and Hafner, Christian (2010) Antiproliferative Effects of Rapamycin and Celecoxib in Angiosarcoma Cell Lines. ANTICANCER RESEARCH, 30 (10). pp. 4017-4023. ISSN 0250-7005,
Full text not available from this repository. (Request a copy)Abstract
Background/Aim: Beyond their primary field of application some well-established drugs exhibit antitumour effects in a variety of cancers. The aim of this study was to investigate the effects of the COX2 inhibitor celecoxib and the mTOR antagonist rapamycin on angiosarcoma cell lines. Materials and Methods: Cell proliferation was measured in ASM, ISOS 1 and ISO HAS angiosarcoma cell lines with the BrdU assay. Results: In all angiosarcoma cell lines, celecoxib as well as rapamycin inhibited cell growth in a dose-dependent manner. In ASM and ISOS 1, but not in ISO HAS angiosarcoma cells, additive growth inhibitory effects were detected by combining both agents. Conclusion: Our results indicate that angiosarcoma cell proliferation can be inhibited by subtoxic doses of rapamycin and celecoxib. Due to their direct and stroma-mediated anticancer activities, mTOR antagonists and COX2 inhibitors represent very promising drugs in the palliative treatment of angiosarcoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOMETRIAL CANCER-CELLS; PHASE-II TRIAL; HUMAN HEPATOCELLULAR-CARCINOMA; RENAL-TRANSPLANT RECIPIENTS; SOFT-TISSUE SARCOMA; KAPOSIS-SARCOMA; CYCLOOXYGENASE-2-INDEPENDENT MECHANISM; ANGIOSTATIC THERAPY; GROWTH-INHIBITION; ADVANCED MELANOMA; Rapamycin; mTOR; celecoxib; COX 2; angiosarcoma; endothelial tumour |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Jul 2020 09:43 |
| Last Modified: | 08 Jul 2020 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24040 |
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