Buettner, Roland and Bettermann, I. and Hechtl, C. and Gaebele, E. and Hellerbrand, C. and Schoelmerich, J. and Bollheimer, L. C. (2010) Dietary Folic Acid Activates AMPK and Improves Insulin Resistance and Hepatic Inflammation in Dietary Rodent Models of the Metabolic Syndrome. HORMONE AND METABOLIC RESEARCH, 42 (11). pp. 769-774. ISSN 0018-5043,
Full text not available from this repository. (Request a copy)Abstract
The AMP activated kinase plays an important role in metabolic control, and pharmacologic enhancement of AMPK activity is used to improve insulin resistance. We hypothesized that high dose of folic acid supplementation might improve insulin sensitivity and hepatic inflammation and examined this by a dietary intervention in (a) the high fat fed rat model of the metabolic syndrome, which shows sole hepatic steatosis as well as (b) in rats fed with a high cholesterol, high cholate diet inducing nonalcoholic steatohepatitis (NASH). Male Wistar rats were fed with folic acid supplemented (40 mg/kg) high fat diet [ based on lard, fat content 25 % (wt/wt)] or NASH inducing diet (containing 15 % fat, 1.25% cholesterol, 0.5% sodium cholate). Metabolic profiling was performed by measuring the animals' visceral fat pads, fasting plasma glucose, insulin, and adipokines as well as in vivo insulin tolerance tests. Hepatic steatosis and inflammation were analyzed semiquantitatively by histological analysis. Folic acid supplementation reduced visceral obesity and improved plasma adiponectin levels. In vivo insulin sensitivity was improved, and in HF-FA rats folic acid increased activation of hepatic AMPK. Further, folic acid supplementation improved hepatic inflammation in animals fed with NASH-inducing diet. Dietary folic acid improved parameters of insulin resistance and hepatic inflammation in rodent models. This might be due to an increased AMPK activation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-FAT DIETS; PROTEIN-KINASE; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE; NONALCOHOLIC STEATOHEPATITIS; COLORECTAL CARCINOGENESIS; GLUCOSE-TRANSPORT; ATHEROGENIC DIET; SUPPLEMENTATION; MUSCLE; FOLATE; folate; nonalcoholic steatohepatitis; insulin action |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Jul 2020 05:33 |
| Last Modified: | 13 Jul 2020 05:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24075 |
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