Wagner, Charlotte and Jobs, Alexander and Schweda, Frank and Kurtz, Lisa and Kurt, Birguel and Lopez, Maria L. Sequeira and Gomez, R. Ariel and Van Veen, Toon A. B. and De Wit, Cor and Kurtz, Armin (2010) Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension. KIDNEY INTERNATIONAL, 78 (8). pp. 762-768. ISSN 0085-2538, 1523-1755
Full text not available from this repository. (Request a copy)Abstract
Renin-producing juxtaglomerular cells are connected to each other and to endothelial cells of afferent arterioles by gap junctions containing Connexin 40 (Cx40), abundantly expressed by these two cell types. Here, we generated mice with cell-specific deletion of Cx40 in endothelial and in renin-producing cells, as its global deletion caused local dissociation of renin-producing cells from endothelial cells, renin hypersecretion, and hypertension. In mice lacking endothelial Cx40, the blood pressure, renin-producing cell distribution, and the control of renin secretion were similar to wild-type mice. In contrast, mice deficient for Cx40 in renin-producing cells were hypertensive and these cells were ectopically localized. Although plasma renin activity and kidney renin mRNA levels of these mice were not different from controls, the negative regulation of renin secretion by pressure was inverted to a positive feedback in kidneys lacking Cx40 in renin-producing cells. Thus, our findings show that endothelial Cx40 is not essential for the control of renin expression and/or release. Cx40 in renin-producing cells is required for their correct positioning in the juxtaglomerular area and the control of renin secretion by pressure. Kidney International (2010) 78, 762-768; doi: 10.1038/ki.2010.257; published online 4 August 2010
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VIVO; EXPRESSION; VASCULATURE; ENDOTHELIUM; DILATIONS; PRESSURE; RATS; afferent arteriole; blood pressure; renal hypertension; renin angiotensin system |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jul 2020 12:30 |
| Last Modified: | 09 Jul 2020 12:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24099 |
Actions (login required)
 |
View Item |
