Bayersdorfer, Florian and Voigt, Aaron and Schneuwly, Stephan and Botella, Jose A. (2010) Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. NEUROBIOLOGY OF DISEASE, 40 (1). pp. 113-119. ISSN 0969-9961, 1095-953X
Full text not available from this repository. (Request a copy)Abstract
Parkinson's disease has been found to be caused by both, genetic and environmental factors. Despite the diversity of causes involved, a convergent pathogenic mechanism might underlie the special vulnerability of dopaminergic neurons in different forms of Parkinsonism. In recent years, a number of reports have proposed dopamine as a common player responsible in the loss of dopaminergic neurons independent of its etiology. Using RNAi lines we were able to generate flies with drastically reduced dopamine levels in the dopaminergic neurons. Combining these flies with a chemically induced Parkinson model (rotenone) and a familial form of Parkinson (mutant alpha-synuclein) we were able to show a strong reduction of neurotoxicity and a protection of the dopaminergic neurons when cellular dopamine levels were reduced. These results show that dopamine homeostasis plays a central role for the susceptibility of dopaminergic neurons to environmental and genetic factors in in vivo models of Parkinson disease. (C) 2010 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALPHA-SYNUCLEIN; SELECTIVE NEURODEGENERATION; PESTICIDE EXPOSURE; INDUCED TOXICITY; NEURONAL DEATH; PC12 CELLS; ROTENONE; MELANOGASTER; MUTATION; Dopamine; Cell death; Parkinson's disease; Drosophila; alpha-Synuclein; Rotenone; Neuroprotection |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jul 2020 12:49 |
| Last Modified: | 09 Jul 2020 12:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24106 |
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