Hoegl, Birgit and Oertel, Wolfgang H. and Stiasny-Kolster, Karin and Geisler, Peter and Benes, Heike and Garcia-Borreguero, Diego and Trenkwalder, Claudia and Poewe, Werner and Schollmayer, Erwin and Kohnen, Ralf (2010) Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch. BMC NEUROLOGY, 10: 86. ISSN 1471-2377,
Full text not available from this repository. (Request a copy)Abstract
Background: Rotigotine is a unique dopamine agonist with activity across D1 through D5 receptors as well as select adrenergic and serotonergic sites. This study reports the 2-year follow-up safety and efficacy data of an ongoing open-label multicenter extension study (NCT00498186) of transdermal rotigotine in patients with moderate to severe restless legs syndrome (RLS). Methods: Patients received a once-daily patch application of an individually optimized dose of rotigotine between 0.5 mg/24 h to 4 mg/24 h. Safety assessments included adverse events (AEs) and efficacy was measured by the International RLS Study Group Severity Rating Scale (IRLS), RLS-6 scales and Clinical Global Impression (CGI). Quality of life (QoL) was measured by QoL-RLS. Results: Of 310 patients who completed a 6-week placebo-controlled trial (SP709), 295 (mean age 58 +/- 10 years, 66% females) were included in the open-label trial SP710. 64.7% (190/295 patients) completed the 2-year follow-up; 29 patients discontinued during the second year. Mean daily rotigotine dose after 2 years was 2.93 +/- 1.14 mg/24 h with a 2.9% dose increase from year 1. Rotigotine was generally well tolerated. The rate of typical dopaminergic side effects, nausea and fatigue, was low (0.9% and 2.3%, respectively) during the second year; application site reactions were frequent but lower than in year 1 (16.4% vs. 34.5%). The IRLS total score improved from baseline of SP709 (27.8 +/- 5.9) by 17.2 +/- 9.2 in year 2 completers. Similar improvements were observed in RLS-6 scales, CGI scores and QoL-RLS. The responder rate in the CGI change item 2 ("much" and "very much" improved) was 95% after year 2. Conclusions: Transdermal rotigotine is an efficacious and well-tolerated long-term treatment option for patients with moderate to severe RLS with a high retention rate during 2 years of therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLACEBO-CONTROLLED TRIAL; LONG-TERM SAFETY; DOUBLE-BLIND; OPEN-LABEL; PARKINSONS-DISEASE; PRAMIPEXOLE; CABERGOLINE; MULTICENTER; 6-MONTH; HEALTH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Jul 2020 06:34 |
| Last Modified: | 13 Jul 2020 06:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24161 |
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