Schmidt-Wilcke, Tobias and Hierlmeier, Stefanie and Leinisch, Elke (2010) Altered Regional Brain Morphology in Patients With Chronic Facial Pain. HEADACHE, 50 (8). pp. 1278-1285. ISSN 0017-8748,
Full text not available from this repository.Abstract
Background.-Persistent idiopathic facial pain (PIFP) is defined as a persistent, unilateral facial pain, not associated with sensory loss or other physical signs and with no obvious structural abnormalities that would sufficiently explain pain experience. Objective.-We were interested whether there is evidence of altered brain morphology in patients with PIFP as it has been described in other chronic pain conditions. Methods.-Using voxel-based morphometry we investigated regional gray matter volume in 11 PIFP patients and 11 age- and sex-matched healthy controls. Furthermore we calculated lateralization indices (LI) to investigate differences in interhemispheric gray matter asymmetries. Results.-We report a decrease in gray matter volume in the left anterior cingulate gyms and left temporo-insular region, as well as in the left and right sensory-motor area, projecting to the representational area of the face. Analyses of LI values demonstrated an increased rightward asymmetry in the middle-anterior insular cortex in patients in comparison with healthy controls. Conclusion.-Our data support previous findings showing that chronic pain states are display-altered brain morphology in brain regions know to be part of the pain system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC BACK-PAIN; NEUROPATHIC PAIN; GRAY-MATTER; SOMATOSENSORY CORTEX; FUNCTIONAL-CHANGES; MECHANISMS; LATERALIZATION; REPRESENTATION; ASYMMETRIES; INTENSITY; facial pain; chronic pain; brain morphology; brain imaging; lateralization index |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2020 04:53 |
| Last Modified: | 15 Jul 2020 04:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24232 |
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