El Chartouni, Carol and Schwarzfischer, Lucia and Rehli, Michael (2010) Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. IMMUNOBIOLOGY, 215 (9-10). pp. 821-825. ISSN 0171-2985,
Full text not available from this repository. (Request a copy)Abstract
Interleukin (IL)-4 is a central regulator of T helper 2 (Th2) immune responses, and also has a major impact on innate immune cells. This cytokine primes macrophages for immune responses to parasites and induces a distinct macrophage phenotype that may also promote tissue repair. IL-4 signaling in macrophages is primarily mediated by the transcription factor signal transducer and activator of transcription 6 (Stat6), which in turn regulates a number of secondary DNA binding proteins that may participate in shaping the resulting phenotype. The impact of secondary transcription factors on IL-4-treated macrophages, however, is largely unknown. Here we show that interferon regulatory factor 4 (Irf4) is strongly induced on RNA and protein level in bone marrow-derived macrophages upon priming with IL-4. Using microarray-based whole genome expression analysis, we also demonstrate that a subset of IL-4 regulated genes, including several MHC-II genes, Ciita, Cyp1b1, and Il1rn, are dysregulated in Irf4-deficient macrophages. The presented data suggests a non-redundant role for Irf4 in shaping the phenotype of alternatively primed macrophages. (C) 2010 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-DIFFERENTIATION; GENE-EXPRESSION; BINDING-PROTEIN; TRANSCRIPTION; ACTIVATION; RECEPTOR; IL-4; INDUCTION; MECHANISM; CYTOKINES; Alternative macrophage activation; Cytokine response; Gene regulation; Mutant mouse strain; Transcriptional profiling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2020 05:25 |
| Last Modified: | 15 Jul 2020 05:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24240 |
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