Gekeler, Florian and Kobuch, Karin and Blatsios, Georgios and Zrenner, Eberhart and Shinoda, Kei (2010) Repeated Transchoroidal Implantation and Explantation of Compound Subretinal Prostheses: An Exploratory Study in Rabbits. JAPANESE JOURNAL OF OPHTHALMOLOGY, 54 (5). pp. 467-475. ISSN 0021-5155,
Full text not available from this repository. (Request a copy)Abstract
Purpose: For human trials with retinal prostheses it is mandatory to develop procedures to safely explant and possibly reimplant the devices. This prompted us to investigate in a small exploratory study the safety of repeated transchoroidal implantation and explantation procedures of complex subretinal devices in laboratory animals. Methods: Repeated transchoroidal surgery was performed in four rabbits. The rabbits were examined by clinical examination and funduscopy. Function was assessed by electroretinography and cortical recordings following light and subretinal electrical stimulation. Sections of the retina and of the implantation channel were examined by light microscopy. Results: Using the same access route, repeated transchoroidal subretinal implantation surgery was successfully performed in all cases. Fixation of implants was stable for up to 13 months; retinas remained attached at all examination dates. Electroretinograms and visual evoked cortical potential proved retinal and visual pathway integrity. Subretinal electrical stimulation elicited retinal and cortical responses. While retinal morphology at earlier stages was found to be essentially unaltered, atrophic disorganization in the region of the subretinal channel was observed after 10 months and after subretinal electrical stimulation. Conclusions: Repeated transchoroidal surgery can be safely performed for implantation, explantation, and reimplantation of subretinal devices in rabbits. With modifications, we believe the technique can be applied in human surgery. Jpn J Ophthalmol 2010;54:467-475 (C)Japanese Ophthalmological Society 2010
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPTICAL COHERENCE TOMOGRAPHY; LONG-TERM IMPLANTATION; ELECTRICAL-STIMULATION; RETINAL PROSTHESIS; RETINITIS-PIGMENTOSA; ARTIFICIAL VISION; FEASIBILITY; PIGS; POTENTIALS; DEVICES; implant; prosthesis; rabbit; retina; surgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2020 05:40 |
| Last Modified: | 15 Jul 2020 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24246 |
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