Wolff, Johannes E. A. and Mohiuddin, Kamran and Jorch, Norbert and Graf, Norbert and Wagner, Sabine and Vats, Tribahwan and Gnekow, Astrid (2010) Measuring Performance Status in Pediatric Patients With Brain Tumors-Experience of the HIT-GBM-C Protocol. PEDIATRIC BLOOD & CANCER, 55 (3). pp. 520-524. ISSN 1545-5009, 1545-5017
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Background. Measuring the quality of life or performance status in pediatric neurooncology has proven a challenge. Here, we report in a treatment protocol for pediatric patients with high-grade glioma and diffuse intrinsic pontine glioma. Procedure. The Fertigkeitenskala Munster-Heidelberg (FMH) is a 56-item quantitative measure of health status. The number of yes answers is transformed to age-dependent percentiles. Physicians were also asked the patients's health status by their own judgment on a 1-5 scale: normal, mild handicap, age-normal activity severely reduced but patient not in bed, in bed, and in ICU. Results. Assessments were available from 50 of 97 eligible patients. For 22 patients both questionnaire and the physicians score obtained. At the beginning of the treatment, only 5 patients scored over 40 FMH%, and 4 of these survived. Of 16 patients who initially scored less than 40 FMH%, 15 died. During later assessments, most FMH measures became gradually worse. FMH scores improved in three patients. The physician's judgment was documented at diagnosis and during treatment (n =50). Per physician, 22% of the patients were normal before chemotherapy, decreasing to 16% in the middle of the protocol. At diagnosis only 16% of patients had severely reduced activity, which increased to 30.6% in the middle of the protocol. The FMH% correlated well with the physicians' judgments (P <0.005). Conclusion. The FMH scale is easily obtained and provides a valid assessment of health status. Patients with poor performance at diagnosis had a poorer prognosis. Pediatr Blood Cancer. 2010;55:520-524. (C) 2010 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; HIGH-GRADE GLIOMA; PROGNOSTIC-FACTORS; CHILDHOOD CRANIOPHARYNGIOMA; BREAST-CANCER; SURVIVAL; ETOPOSIDE; brain stem glioma; CNS tumors; psychosocial; quality of life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2020 08:23 |
| Last Modified: | 15 Jul 2020 08:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24285 |
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