Berding, Georg and Geisler, Siegfried and Melter, Michael and Marquardt, Patricia and Luehr, Astrid and Scheller, Friedemann and Knoop, Bernd O. and Pfister, Eva-Doreen and Pape, Lars and Bischoff, Lutz and Knapp, Wolfram H. and Ehrich, Jochen H. H. (2010) Estimation of glomerular filtration rate in liver-transplanted children: Comparison of simplified procedures using 51Cr-EDTA and endogenous markers with Sapirstein's method as a reference standard. PEDIATRIC TRANSPLANTATION, 14 (6). pp. 786-795. ISSN 1397-3142, 1399-3046
Full text not available from this repository. (Request a copy)Abstract
This study evaluated simple procedures for GFR determination in 48 liver-transplanted children. After injection of 51Cr-EDTA, blood samples were obtained up to four h, and activity retention in the body was measured for 60 min with scintillation probes. As a reference, GFR was calculated according to Sapirstein. Simplified calculations were performed according to Brochner-Mortensen, Russel, Devaux and Oberhausen. Additionally, GFR was determined using plasma creatinine and cystatin C according to Schwartz and Filler, respectively. The reference revealed mildly reduced GFR (62 +/- 20 mL/min/1.73 m2). Russel's method provided the highest degree of correlation (r2 = 0.95), the smallest bias in GFR determination (-2%), and only one false exclusion plus one false diagnosis of chronic kidney disease. Oberhausen's method with blood sampling at one h post-injection performed slightly worse (r2 = 0.67, bias: 3%). All other methods resulted in significantly different GFR estimates compared to the reference. Nevertheless, notably, the second narrowest 95% limits of agreement (-31% to 45%) was observed using cystatin C. In conclusion, this data implies to prefer Russel's method as a simplified procedure, and if patients cannot be available long enough (four h) for measurements, Oberhausen's method instead. If radiotracer methods are not available at all or for screening GFR, cystatin C appears to be the procedure of choice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLASMA CREATININE CONCENTRATION; CHRONIC KIDNEY-DISEASE; RENAL-FUNCTION; CYSTATIN-C; SCHWARTZ FORMULA; FOLLOW-UP; CLEARANCE; RECIPIENTS; LONG; SERUM; glomerular filtration rate; liver-transplanted children; chronic kidney disease; 51Cr-EDTA; endogenous marker of glomerular filtration rate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2020 08:30 |
| Last Modified: | 15 Jul 2020 08:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24287 |
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