Spaeth, Andreas and Koenig, Burkhard (2010) Binding of a hemoregulatory tetrapeptide by a bis-guanidinium crown ether. TETRAHEDRON, 66 (32). pp. 6019-6025. ISSN 0040-4020,
Full text not available from this repository. (Request a copy)Abstract
A synthetic receptor for the molecular recognition of a tetrapeptide in aqueous buffer was obtained by combining a luminescent crown ether with two pyrrole-guanidinium moieties. The compound interacts with ammonium carboxylates of complementary geometry and binds the hemoregulatory peptide Ac-Ser-Asp-Lys-Pro with K=7 x 10(3) M(-1) at physiological pH. Shorter fragments and other tetrapeptides show no or significant reduced affinity. The binding of the target peptide to the functionalized crown ether is signalled by an increase of its emission intensity. (c) 2010 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ASP-LYS-PRO; AMINO-ACIDS; LUMINESCENT RECEPTOR; AQUEOUS-SOLUTION; PEPTIDES; COMPLEXATION; RECOGNITION; IMPROVEMENT; MECHANISMS; SWITCHES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2020 09:59 |
| Last Modified: | 15 Jul 2020 09:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24329 |
Actions (login required)
 |
View Item |
