Driemel, Oliver and Escher, Niko and Ernst, Guenther and Melle, Christian and von Eggeling, Ferdinand (2010) S100A8 Cellular Distribution in Normal Epithelium, Hyperplasia, Dysplasia and Squamous Cell Carcinoma and Its Concentration in Serum. ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY, 32 (4). pp. 219-224. ISSN 0884-6812,
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OBJECTIVE: To investigate the function of S100A8, a member of the calcium-binding S100 protein family, in oral tumorigenesis. We analyzed its cellular distribution and its serum level in patients with squamous cell carcinoma and normal controls. STUDY DESIGN: We investigated the histopathologic features by tissue microarrays (TMAs) including 8 normal, 66 hyperplastic and dysplastic and 26 oral spumous cell carcinoma (OSCC) tissue cores. The serum level of S100A8 was measured by an enzyme-linked immunosorbent assay using 33 healthy volunteers, 20 patients with hyperproliferative lesions and 23 patients with OSCC. RESULTS: The TMA analysis resulted in different findings. The strongest expression of S100A8 was found in severe dysplasias and carcinoma in situ. In tumor tissue an increased expression occurred only focally. In the normal tissue cores the epithelium showed a moderate reaction, but basal and parabasal cells were completely negative. The serum levels of S100A8 were marginally reduced in cancer patients. The expression between healthy controls and patients with hyperproliferative lesions displayed no difference. CONCLUSION: The expression of S100A8 is helpful only in the transition from severe dysplastic tissue to cancer. (Anal Quant Cytol Histol 2010;32:219-224)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CALCIUM-BINDING PROTEINS; ORAL BRUSH BIOPSIES; NORMAL COLON MUCOSA; NECK-CANCER; TELOMERASE ACTIVITY; COLORECTAL-CARCINOMA; MEDICAL PROGRESS; MATCHED SETS; HEAD; EXPRESSION; immunohistochemistry; oral neo-plasms; S100A8; squamous cell carcinoma; tissue microarrays |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jul 2020 06:01 |
| Last Modified: | 20 Jul 2020 06:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24341 |
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