Jiao, Li and de Gonzalez, Amy Berrington and Hartge, Patricia and Pfeiffer, Ruth M. and Park, Yikyung and Freedman, D. Michal and Gail, Mitchell H. and Alavanja, Michael C. R. and Albanes, Demetrius and Freeman, Laura E. Beane and Chow, Wong-Ho and Huang, Wen-Yi and Hayes, Richard B. and Hoppin, Jane A. and Ji, Bu-tian and Leitzmann, Michael F. and Linet, Martha S. and Meinhold, Cari L. and Schairer, Catherine and Schatzkin, Arthur and Virtamo, Jarmo and Weinstein, Stephanie J. and Zheng, Wei and Stolzenberg-Solomon, Rachael Z. (2010) Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts. CANCER CAUSES & CONTROL, 21 (8). pp. 1305-1314. ISSN 0957-5243,
Full text not available from this repository. (Request a copy)Abstract
To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes. In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis. In a random-effects meta-analysis, for every 5 kg/m(2) increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to < 25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to < 30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to < 35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m(2) increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08). The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FRANCISCO BAY AREA; PHYSICAL-ACTIVITY; MALE SMOKERS; WOMENS HEALTH; UNITED-STATES; US COHORT; OBESITY; METAANALYSIS; MORTALITY; HEIGHT; Pancreatic cancer; Body mass index; Pooled analysis; Prospective cohort; Effect modification |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jul 2020 06:59 |
| Last Modified: | 20 Jul 2020 06:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24353 |
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