Rieder, Florian and Schleder, Stephan and Wolf, Alexandra and Dirmeier, Andrea and Strauch, Ulrike and Obermeier, Florian and Lopez, Rocio and Spector, Larissa and Fire, Ella and Yarden, Jennifer and Rogler, Gerhard and Dotan, Nir and Klebl, Frank (2010) Serum Anti-Glycan Antibodies Predict Complicated Crohn's Disease Behavior: A Cohort Study. INFLAMMATORY BOWEL DISEASES, 16 (8). pp. 1367-1375. ISSN 1078-0998, 1536-4844
Full text not available from this repository. (Request a copy)Abstract
Background: A high proportion of patients with Crohn's disease (CD) over time develop complications like fistulae and strictures, requiring surgery. We tested a panel of antiglycan antibodies for predicting the occurrence of complications and CD-related surgery in an adult patient cohort. Methods: Serum samples of 149 CD patients of the German inflammatory bowel disease (IBD) network were tested for the presence of anti-laminarin IgA (Anti-L), anti-chitin IgA (Anti-C), anti-chitobioside IgA (ACCA), anti-laminaribioside IgG (ALCA), anti-mannobioside IgG (AMCA), and anti-Saccaromyces cerevisiae IgG (gASCA) carbohydrate antibodies by enzyme-linked immunosorbent assay (ELISA) (IBDX (R) panel, Glycominds, Lod, Israel) in a blinded fashion. Clinical data were available on occurrence of complicated disease or CD-related surgery as well as disease activity, onset, and location. Results: The median follow-up of the patients without any previous complication or surgery at time of sample procurement was 53.7 months. Overall, 26.3% developed a complication and 17.1% underwent CD-related surgery, respectively. Positivity for gASCA, AMCA, ACCA, and Anti-L alone or an increasing frequency of positive serum antibodies independently predicted a faster progression toward a more severe disease course. Once a complication or surgery had occurred only positivity for Anti-L or more than 3 markers out of the whole panel indicated progression to an additional surgery or complication. The antibody status of most patients remained stable over time. Conclusions: This is the first study showing the clinical value of serum antiglycan antibodies for prediction of a more complicated disease course in adult patients with CD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; TERM-FOLLOW-UP; SEROLOGICAL MARKERS; IMMUNE-RESPONSES; CLINICAL-COURSE; SURGERY; UTILITY; PATTERN; IMPACT; RISK; Crohn's; prediction; anti-L; anti-C; antibody |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jul 2020 08:59 |
| Last Modified: | 20 Jul 2020 08:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24390 |
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