Rheumatoid arthritis and autoimmune hemolysis. B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease

Lehmann, P. and Hartung, W. and Ehrenstein, B. and Schoelmerich, J. and Fleck, M. (2010) Rheumatoid arthritis and autoimmune hemolysis. B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease. ZEITSCHRIFT FUR RHEUMATOLOGIE, 69 (6). pp. 557-560. ISSN 0340-1855, 1435-1250

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Abstract

Autoimmune hemolysis is a rare complication of systemic rheumatic diseases. We report on a 68-year-old female patient with established, long-standing rheumatoid arthritis, who complained of progressive weakness and worsening of her arthralgia under therapy with leflunomide. Physical and laboratory examination revealed autoimmune hemolysis due to cold agglutinin disease. As hemolysis and arthritis were refractory to steroid treatment, B-cell depletion with rituximab was performed leading to a marked reduction of hemolytic parameters as well as remission of her rheumatoid arthritis.

Item Type: Article
Uncontrolled Keywords: THERAPY; RITUXIMAB; Rheumatoid arthritis; Autoimmune hemolysis; Cold agglutinin disease; Rituximab
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin I
Depositing User: Dr. Gernot Deinzer
Date Deposited: 22 Jul 2020 06:10
Last Modified: 22 Jul 2020 06:10
URI: https://pred.uni-regensburg.de/id/eprint/24442

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