Movahedi, Kiavash and Laoui, Damya and Gysemans, Conny and Baeten, Martijn and Stange, Geert and Van den Bossche, Jan and Mack, Matthias and Pipeleers, Daniel and Veld, Peter In't and De Baetselier, Patrick and Van Ginderachter, Jo A. (2010) Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes. CANCER RESEARCH, 70 (14). pp. 5728-5739. ISSN 0008-5472, 1538-7445
Full text not available from this repository. (Request a copy)Abstract
Tumor-associated macrophages (TAM) form a major component of the tumor stroma. However, important concepts such as TAM heterogeneity and the nature of the monocytic TAM precursors remain speculative. Here, we show for the first time that mouse mammary tumors contained functionally distinct subsets of TAMs and provide markers for their identification. Furthermore, in search of the TAM progenitors, we show that the tumor-monocyte pool almost exclusively consisted of Ly6C(hi)CX(3)CR1(low) monocytes, which continuously seeded tumors and renewed all nonproliferating TAM subsets. Interestingly, gene and protein profiling indicated that distinct TAM populations differed at the molecular level and could be classified based on the classic (M1) versus alternative (M2) macrophage activation paradigm. Importantly, the more M2-like TAMs were enriched in hypoxic tumor areas, had a superior proangiogenic activity in vivo, and increased in numbers as tumors progressed. Finally, it was shown that the TAM subsets were poor antigen presenters, but could suppress T-cell activation, albeit by using different suppressive mechanisms. Together, our data help to unravel the complexities of the tumor-infiltrating myeloid cell compartment and provide a rationale for targeting specialized TAM subsets, thereby optimally "re-educating" the TAM compartment. Cancer Res; 70(14); 5728-39. (C)2010 AACR.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; INFLAMMATORY DENDRITIC CELLS; SUPPRESSOR-CELLS; TIE2-EXPRESSING MONOCYTES; BLOOD MONOCYTES; CTL SUPPRESSION; BEARING MICE; BONE-MARROW; CANCER; PROGRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jul 2020 08:23 |
| Last Modified: | 22 Jul 2020 08:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24458 |
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