Isbary, G. and Morfill, G. and Schmidt, H. U. and Georgi, M. and Ramrath, K. and Heinlin, J. and Karrer, S. and Landthaler, M. and Shimizu, T. and Steffes, B. and Bunk, W. and Monetti, R. and Zimmermann, J. L. and Pompl, R. and Stolz, W. (2010) A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. BRITISH JOURNAL OF DERMATOLOGY, 163 (1). pp. 78-82. ISSN 0007-0963, 1365-2133
Full text not available from this repository. (Request a copy)Abstract
P>Background Bacterial colonization of chronic wounds slows healing. Cold atmospheric plasma has been shown in vitro to kill a wide range of pathogenic bacteria. Objectives To examine the safety and efficiency of cold atmospheric argon plasma to decrease bacterial load as a new medical treatment for chronic wounds. Patients and methods Thirty-eight chronic infected wounds in 36 patients were treated in a prospective randomized controlled phase II study with 5 min daily cold atmospheric argon plasma in addition to standard wound care. The patient acted as his or her own control. Bacterial species were detected by standard bacterial swabs and semiquantitative changes by nitrocellulose filters. Plasma setting and safety had been determined in a preceding phase I study. Results Analysis of 291 treatments in 38 wounds found a highly significant (34%, P < 10-6) reduction of bacterial load in treated wounds, regardless of the type of bacteria. No side-effects occurred and the treatment was well tolerated. Conclusions Cold atmospheric argon plasma treatment is potentially a safe and painless new technique to decrease bacterial load of chronic wounds and promote healing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FULL-FACIAL REJUVENATION; INFECTION; argon plasma; chronic wounds; cold atmospheric plasma; infection; MRSA; plasma medicine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2020 08:15 |
| Last Modified: | 27 Jul 2020 08:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24478 |
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