Schuetz, Christian and Oelke, Mathias and Schneck, Jonathan P. and Mackensen, Andreas and Fleck, Martin (2010) Killer artificial antigen-presenting cells: the synthetic embodiment of a 'guided missile'. IMMUNOTHERAPY, 2 (4). pp. 539-550. ISSN 1750-743X, 1750-7448
Full text not available from this repository. (Request a copy)Abstract
At present, the treatment of T-cell-dependent autoimmune diseases relies exclusively on strategies leading to nonspecific suppression of the immune systems causing a substantial reduced ability to control concomitant infections or malignancies. Furthermore, long-term treatment with most drugs is accompanied by several serious adverse effects and does not consequently result in cure of the primary immunological malfunction. By contrast, antigen-specific immunotherapy offers the potential to achieve the highest therapeutic efficiency in accordance with minimal adverse effects. Therefore, several studies have been performed utilizing antigen-presenting cells specifically engineered to deplete alto- or antigen-specific T cells ('guided missiles'). Many of these strategies take advantage of the Fas/Fas ligand signaling pathway to efficiently induce antigen-presenting cell-mediated apoptosis in targeted T cells. In this article, we discuss the advantages and shortcomings of a novel non-cell-based 'killer artificial antigen-presenting cell' strategy, developed to overcome obstacles related to current cell-based approaches for the treatment of T-cell-mediated autoimmunity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8(+) T-CELLS; PRIMARY BILIARY-CIRRHOSIS; PLACEBO-CONTROLLED TRIAL; EXPRESSING FAS LIGAND; EX-VIVO EXPANSION; RESPONSES IN-VIVO; DENDRITIC CELLS; MULTIPLE-SCLEROSIS; METASTATIC MELANOMA; CD95 LIGAND; antigen-presenting cell; apoptosis; artificial; killer artificial antigen-presenting cell; T cell |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Apr 2020 08:17 |
| Last Modified: | 16 Apr 2020 08:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24505 |
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