Wimmer, Peter and Taeuber, Birgit and Spruss, Thilo and Dobner, Thomas (2010) Adenovirus type 5 early encoded proteins of the E1 and E4 regions induce oncogenic transformation of primary rabbit cells. JOURNAL OF GENERAL VIROLOGY, 91. pp. 1828-1833. ISSN 0022-1317, 1465-2099
Full text not available from this repository. (Request a copy)Abstract
Analysis of the molecular mechanisms of viral-mediated oncogenesis has contributed enormously to the understanding of the basic principles of normal/malignant cell growth. Transformation by human adenoviruses is a multi-step process involving the modulation of numerous cellular pathways, leading to inhibition of apoptosis and growth arrest. However, the molecular mechanism of how the adenovirus oncogenes facilitate transformation of rodent cells, while concurrently failing to do so for human cells, remains elusive. In this report, we demonstrate for the first time that the transformation capabilities of adenovirus type 5 oncogenes are not restricted to rodent cells, but include cells of the related mammalian order Lagomorpha, inducing considerable morphological alterations, enhanced cell growth and tumour induction in vivo. Furthermore, the established cell lines may represent a suitable tool for further development to generate E4-mutated adenoviruses, which has so far been difficult as mutations within the E4 region often prove to be lethal without a helper-cell system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN-EMBRYO RETINOBLASTS; P53 TUMOR-SUPPRESSOR; E4ORF6 PROTEIN; MALIGNANT-TRANSFORMATION; 55-KILODALTON PROTEIN; 55-KDA ONCOPROTEIN; SIMIAN VIRUS-40; LIGASE COMPLEX; DNA; DEGRADATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2020 10:42 |
| Last Modified: | 27 Jul 2020 10:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24514 |
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