Sinner, Moritz F. and Reinhard, Wibke and Mueller, Martina and Beckmann, Britt-Maria and Martens, Eimo and Perz, Siegfried and Pfeufer, Arne and Winogradow, Janina and Stark, Klaus and Meisinger, Christa and Wichmann, H. -Erich and Peters, Annette and Riegger, Guenter A. J. and Steinbeck, Gerhard and Hengstenberg, Christian and Kääb, Stefan (2010) Association of Early Repolarization Pattern on ECG with Risk of Cardiac and All-Cause Mortality: A Population-Based Prospective Cohort Study (MONICA/KORA). PLOS MEDICINE, 7 (7): e1000314. ISSN 1549-1277,
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Background Early repolarization pattern (ERP) on electrocardiogram was associated with idiopathic ventricular fibrillation and sudden cardiac arrest in a case-control study and with cardiovascular mortality in a Finnish community-based sample. We sought to determine ERP prevalence and its association with cardiac and all-cause mortality in a large, prospective, population-based case-cohort study (Monitoring of Cardiovascular Diseases and Conditions [MONICA]/KORA [Cooperative Health Research in the Region of Augsburg]) comprised of individuals of Central-European descent. Methods and Findings: Electrocardiograms of 1,945 participants aged 35-74 y, representing a source population of 6,213 individuals, were analyzed applying a case-cohort design. Mean follow-up was 18.9 y. Cause of death was ascertained by the 9th revision of the International Classification of Disease (ICD-9) codes as documented in death certificates. ERP-attributable effects on mortality were determined by a weighted Cox proportional hazard model adjusted for covariables. Prevalence of ERP was 13.1% in our study. ERP was associated with cardiac and all-cause mortality, most pronounced in those of younger age and male sex; a clear ERP-age interaction was detected (p = 0.005). Age-stratified analyses showed hazard ratios (HRs) for cardiac mortality of 1.96 (95% confidence interval [CI] 1.05-3.68, p = 0.035) for both sexes and 2.65 (95% CI 1.21-5.83, p = 0.015) for men between 35-54 y. An inferior localization of ERP further increased ERP-attributable cardiac mortality to HRs of 3.15 (95% CI 1.58-6.28, p = 0.001) for both sexes and to 4.27 (95% CI 1.90-9.61, p, 0.001) for men between 35-54 y. HRs for all-cause mortality were weaker but reached significance. Conclusions: We found a high prevalence of ERP in our population-based cohort of middle-aged individuals. ERP was associated with about a 2- to 4-fold increased risk of cardiac mortality in individuals between 35 and 54 y. An inferior localization of ERP was associated with a particularly increased risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AUGSBURG CASE-COHORT; SUDDEN-DEATH; QT INTERVAL; HEART-RATE; ELECTROCARDIOGRAM; DESIGN; VARIANT; WOMEN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2020 12:49 |
| Last Modified: | 27 Jul 2020 12:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24530 |
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