Arlt, Matthias and Philipp, Alois and Voelkel, Sabine and Rupprecht, Leopold and Mueller, Thomas and Hilker, Michael and Graf, Bernhard M. and Schmid, Christof (2010) Extracorporeal membrane oxygenation in severe trauma patients with bleeding shock. RESUSCITATION, 81 (7). pp. 804-809. ISSN 0300-9572,
Full text not available from this repository. (Request a copy)Abstract
Aim of the study: Death to trauma is caused by disastrous injuries on scene, bleeding shock or acute respiratory failure (ARDS) induced by trauma and massive blood transfusion. Extracorporeal membrane oxygenation (ECMO) can be effective in severe cardiopulmonary failure, but preexisting bleeding is still a contraindication for its use. We report our first experiences in application of initially heparin-free ECMO in severe trauma patients with resistant cardiopulmonary failure and coexisting bleeding shock retrospectively and describe blood coagulation management on ECMO. Methods: From June 2006 to June 2009 we treated adult trauma patients (n = 10, mean age: 32 14 years, mean ISS score 73 +/- 4) with percutaneous veno-venous (v-v) ECMO for pulmonary failure (n = 7) and with veno-arterial (v-a) ECMO in cardiopulmonary failure (n = 3). Diagnosis included polytrauma (n = 9) and open chest trauma (n = 1). We used a new miniaturised ECMO device (PLS-Set, MAQUET Cardiopulmonary AG, Hechingen, Germany) and performed initially heparin-free ECMO. Results: Prior to ECMO median oxygenation ratio (OR) was 47 (36-90) mmHg, median paCO(2) was 67 (36-89) mm Hg and median norepinephrine demand was 3.0 (1.0-13.5) mg/h. Cardiopulmonary failure was treated effectively with ECMO and systemic gas exchange and blood flow improved rapidly within 2 h on ECMO in all patients (median OR 69 (52-263) mm Hg, median paCO(2) 41 (22-85) mm Hg. 60% of our patients had recovered completely. Conclusions: Initially heparin-free ECMO support can improve therapy and outcome even in disastrous trauma patients with coexisting bleeding shock. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MASSIVE BLOOD-TRANSFUSION; CARDIOPULMONARY FAILURE; LIFE-SUPPORT; COAGULOPATHY; ECMO; HYPOTHERMIA; INJURIES; ACIDOSIS; SYSTEM; LUNG; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2020 12:55 |
| Last Modified: | 27 Jul 2020 12:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24533 |
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