Ikenberg, Kristian and Fritzsche, Florian R. and Zuerrer-Haerdi, Ursina and Hofmann, Irina and Hermanns, Thomas and Seifert, Helge and Muentener, Michael and Provenzano, Maurizio and Sulser, Tullio and Behnke, Silvia and Gerhardt, Josefine and Mortezavi, Ashkan and Wild, Peter and Hofstaedter, Ferdinand and Burger, Maximilian and Moch, Holger and Kristiansen, Glen (2010) Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores. BMC CANCER, 10: 341. ISSN 1471-2407,
Full text not available from this repository. (Request a copy)Abstract
Background: The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods: Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results: IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. Conclusions: Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPRESSION; CARCINOMAS; PROGNOSIS; MELANOMA; SURVIVAL; MARKER; TUMORS; KOC; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2020 13:12 |
| Last Modified: | 27 Jul 2020 13:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/24541 |
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